Drug name: NO-SPA

Active Ingredients:

• Drotaverine hydrochloride

Therapeutic effects of No-Spa: Drotaverine hydrochloride is an isoquinoline spasmolytic. It employs antispasmodic action on the smooth muscle. This is the result of arresting the activity of an enzyme called phosphodiesterase IV. This results to the surge in the amount of adenosine cyclic phosphate also known as cyclo-AMP. Smooth muscles are relaxed as the cyclo-AMP disables the myosin-light-chain kinase.

Drotaverine can lower the tonicity of the insides of smooth muscles, trim down their motion activity and moderately dilate blood vessels. However, it cannot pose effects on CNS and vegetative nervous system.

Indications: No-Spa is used in the treatment of:

• Smooth muscle spasms (postcholecystectomy syndrome, cholecystitis, biliary and gall-bladder dyskinesia, gastric and intestinal colic, renal)
• Spasms caused due to nephrolithiasis, peptic ulcer, duodenal ulcer, inflammation of the mucos membrane of the stomach and duodenum (gastroduodenitis), spasmodic contraction of the pylorus (pylorospasm), tenesmus, inflammation of the rectum (proctitis), and pielitis.
• Peripheral, cerebral and coronary artery spasms.
• Other ailments for which this medicine can be used are post-natal contractions, protracted opening of uteruses pharynx, spasm of uteruses pharynx during birth, premature birth, threat of miscarriage, and algodismenorrhea.

Precautions and Restrictions: Do not use No-Spa under the following circumstances:

• If you are increasingly sensitive or allergic to drotaverine hydrochloride or other ingredients of this medicine
• Renal failure and liver failure
• Congestive Heart Failure (CHF)
• Second and third degree atrioventricular block
• Condition in which the heart has been damaged so much that it is unable to supply enough blood to the organs of the body (Cardiogenic shock)
• Depression of arterial pressure (Arterial hypotension)

Observe caution while taking No-Spa under the following conditions:

• If you have Coronary artery atherosclerosis
• Prostate adenocarcinoma
• Eye conditions that damage the optic nerve (glaucoma)
• If you are pregnant
• If you are a nursing mother

Side effects of No-Spa: Some of the side effects that may occur due to the use of No-Spa are allergic reactions such as: itching and rashes, perspiration, hot flashes, low blood sugar, tachycardia, and cephalalgia.

These are just some of the side effects and these are by no means an exhaustive list of adverse effects caused due to No-Spa. For more information kindly consult your physician, pharmacist, or read the full details presented by the manufacturer.

Interactions: Before using No-Spa it is best to consult your physician and explain to him the treatment or medicines you are using and also get a prescription from your doctor before starting any new drug. This is to make sure that the combination of the two drugs is safe.

• No-Spa reacts with Levodopa to reduce its effectiveness
• No-Spa increases the therapeutic effects of bendazole, papaverine, and other spasmolytics
• No-Spa increases the risk of low blood pressure caused by procainamide, chinidine, and antidepressants
• No-spa decreases the spasmogenic properties of morphine
• Phenobarbital enhances the spasmolytic action of Drotaverine

Additional Information: Always avoid sharing medicines with anyone else. It is advised to avoid using this medicine for any other health conditions. Make sure that the product as well as the syringes and needles are kept out of the reach of the children. Keep in mind that it is dangerous to reuse any material including needles or even syringes.