Drug name: Mildronat

Active Ingredients:

• Mildronate

Therapeutic effect of Mildronat: Mildronate is a structural analogue precedent of the carnitine - gamma-butyrobetaine (GBB). It slows down the activity of the gamma-butyrobetain-hydroxylase. As a result, there is a decrease of carnitine biosynthesis and long-chain fatty acid transport through cell membranes. Mildoronate, also lessens adverse effects by preventing the accumulation of Acyl-CoA and Acyl-carnitine, which are both metabolites of long-chain fatty acids in cells.

Under the conditions of ischemia, Mildronate activates the anaerobic glycolysis and stimulates ATP fabrication. It also transports and restores the balance between oxygen delivery and consumption.

Decline in carnitine absorption triggers the activation of activation gamma-butyrobetaine synthesis. The latter is capable of performing vasodilatating activities. Mildronate has a cardio protective effect. In the event that a chronic congestive heart failure occurs, it intensifies myocardial contractility which allows for the increased tolerance of the organism to physical overload. In patients with a stable stage II or III angina pectoris, Mildronate physical vital that leads to the deteriorating number of angina pectoris attacks.

In cases of acute and chronic ischemic cerebrovascular disruptions, Mildronate makes the cerebral blood flow better in the ischemic region. This promotes reorganization in the flow of blood giving much favour to the ischemic zone. Mildronate also has a tonic effect which avoids functional interruptions of the somatic and vegetative nervous system.

Indications: Mildronat is administered to treat the following:

• Chronic coronary heart disease
• Angina or chest pain
• Heart Failure
• Disorders of the cardiovascular system
• Heart muscle disease (cardiomyopathy)
• Ischemic cerebrovascular diseases

Precautions and Restrictions: Avoid using Mildronate if you are highly sensitive to this medicine or its ingredients. If any one of the below mentioned conditions apply to you then consult a doctor before using this meidicine:

• Pregnancy
• Lactation

Be cautious while using Mildronate, if you are already suffering from chronic renal disease or liver disorder. The effect of this medicine on children below 12 is not known so before using it on a young child talk to a doctor to know more about this medicine.

There are no information about the effect of Mildronate on pregnant women and fetus, so it not right to use this medicine on pregnant women.

The effect of active ingredients of this medicine on nursing babies is not known, so if the lactating mother is administered Mildronate then she has to stop breast feeding the baby. There are no studies to show the effect of this medicine on driving and use of machinery.

Side effects of Mildronate: Users of Mildronate may experience certain side effects that are unintended. These adverse reactions may affect different people in different ways. There is no proof that all the users of this drug will have the below mentioned effects.

If the users experience the following reactions then they should stop using Mildronate at once and visit a medical care provider. The users may experience various allergic reactions, problems in the digestive system, disorders of the heart rate, changes in arterial pressure, cephalalgia, eosinophilia, weakness, and agitation may occur.

These are just some of the side effects and this is by no means an exhaustive list of adverse effects caused due to use of Mildronate. For more information kindly consult your physician, pharmacist or see the full list of details presented with Mildronate.

Interactions: Talk to a doctor before taking any drug to make sure that it does not react with medicines you are already taking. This also includes any over-the-counter or herbal medicine. Mildronate can increase the effectiveness of some cardiovascular agents like peripheral vasodilators, hypotensive agents, beta-adrenoblockers, nifedipine, nitroglycerine, etc. Mildronate can also react with diuretics, cardiac glycosides, antarrhythmic drugs, antiagregants, anticoagulants, antianginal drugs, etc.

Additional Information: Do not share Mildronate with anyone without proper medical prescription. Do not use this medicine in any other type of health related complication. Keep the medicine and syringes away from children to avoid any problem.